ParkinsonCanadaV1, Main, Exploration, bibRecord, 001E85

LINGO1 rs9652490 is associated with Essential Tremor and Parkinson Disease

Identifieur interne : 001E85 ( Main/Exploration ); précédent : 001E84; suivant : 001E86

LINGO1 rs9652490 is associated with Essential Tremor and Parkinson Disease

Auteurs : Carles Vilari O-Güell [États-Unis] ; Owen A. Ross [États-Unis] ; Christian Wider [États-Unis] ; Barbara Jasinska-Myga [États-Unis, Pologne] ; Stephanie A. Cobb [États-Unis] ; Alexandra I. Soto-Ortolaza [États-Unis] ; Jennifer M. Kachergus [États-Unis] ; Brett H. Keeling [États-Unis] ; Justus C. Dachsel [États-Unis] ; Heather L. Melrose [États-Unis] ; Bahareh Behrouz [États-Unis] ; Zbigniew K. Wszolek [États-Unis] ; Ryan J. Uitti [États-Unis] ; Jan O. Aasly [Norvège] ; Alex Rajput [Canada] ; Matthew J. Farrer [États-Unis]

Source :

Parkinsonism & related disorders [ 1353-8020 ] ; 2009.

RBID : PMC:2844122

English descriptors

KwdEn :
- Adult, Aged, Aged, 80 and over, Case-Control Studies, Essential Tremor (genetics), Female, Gene Frequency, Genome-Wide Association Study, Genotype, Humans, International Cooperation, Male, Membrane Proteins (genetics), Middle Aged, Nerve Tissue Proteins (genetics), Parkinson Disease (genetics), Polymorphism, Genetic (genetics).
MESH :
- chemical , genetics : Membrane Proteins, Nerve Tissue Proteins.
- genetics : Essential Tremor, Parkinson Disease, Polymorphism, Genetic.
- Adult, Aged, Aged, 80 and over, Case-Control Studies, Female, Gene Frequency, Genome-Wide Association Study, Genotype, Humans, International Cooperation, Male, Middle Aged.

Abstract

Recently, a variant in LINGO1 (rs9652490) was found to associate with increased risk of essential tremor. We set out to replicate this association in an independent case-control series of essential tremor from North America. In addition, given the clinical and pathological overlap between essential tremor and Parkinson disease, we also evaluate the effect of LINGO1 rs9652490 in two case-control series of Parkinson disease. Our study demonstrates a significant association between LINGO1 rs9652490 and essential tremor (P=0.014) and Parkinson disease (P=0.0003), thus providing the first evidence of a genetic link between both diseases.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844122

DOI: 10.1016/j.parkreldis.2009.08.006
PubMed: 19720553
PubMed Central: 2844122

Affiliations:

Le document en format XML

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 rs9652490 is associated with Essential Tremor and Parkinson Disease</title>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>LINGO1</italic>
 rs9652490 is associated with Essential Tremor and Parkinson Disease</title>
<author><name sortKey="Vilari O Guell, Carles" sort="Vilari O Guell, Carles" uniqKey="Vilari O Guell C" first="Carles" last="Vilari O-Güell">Carles Vilari O-Güell</name>
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<author><name sortKey="Jasinska Myga, Barbara" sort="Jasinska Myga, Barbara" uniqKey="Jasinska Myga B" first="Barbara" last="Jasinska-Myga">Barbara Jasinska-Myga</name>
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<author><name sortKey="Behrouz, Bahareh" sort="Behrouz, Bahareh" uniqKey="Behrouz B" first="Bahareh" last="Behrouz">Bahareh Behrouz</name>
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<author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name>
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<author><name sortKey="Aasly, Jan O" sort="Aasly, Jan O" uniqKey="Aasly J" first="Jan O" last="Aasly">Jan O. Aasly</name>
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<author><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J." last="Farrer">Matthew J. Farrer</name>
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<series><title level="j">Parkinsonism & related disorders</title>
<idno type="ISSN">1353-8020</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Case-Control Studies</term>
<term>Essential Tremor (genetics)</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genome-Wide Association Study</term>
<term>Genotype</term>
<term>Humans</term>
<term>International Cooperation</term>
<term>Male</term>
<term>Membrane Proteins (genetics)</term>
<term>Middle Aged</term>
<term>Nerve Tissue Proteins (genetics)</term>
<term>Parkinson Disease (genetics)</term>
<term>Polymorphism, Genetic (genetics)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Membrane Proteins</term>
<term>Nerve Tissue Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Essential Tremor</term>
<term>Parkinson Disease</term>
<term>Polymorphism, Genetic</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Case-Control Studies</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genome-Wide Association Study</term>
<term>Genotype</term>
<term>Humans</term>
<term>International Cooperation</term>
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<front><div type="abstract" xml:lang="en"><p id="P2">Recently, a variant in <italic>LINGO1</italic>
 (rs9652490) was found to associate with increased risk of essential tremor. We set out to replicate this association in an independent case-control series of essential tremor from North America. In addition, given the clinical and pathological overlap between essential tremor and Parkinson disease, we also evaluate the effect of <italic>LINGO1</italic>
 rs9652490 in two case-control series of Parkinson disease. Our study demonstrates a significant association between <italic>LINGO1</italic>
 rs9652490 and essential tremor (<italic>P</italic>
=0.014) and Parkinson disease (<italic>P</italic>
=0.0003), thus providing the first evidence of a genetic link between both diseases.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
<li>Norvège</li>
<li>Pologne</li>
<li>États-Unis</li>
</country>
<region><li>Trøndelag</li>
</region>
<settlement><li>Trondheim</li>
</settlement>
</list>
<tree><country name="États-Unis"><noRegion><name sortKey="Vilari O Guell, Carles" sort="Vilari O Guell, Carles" uniqKey="Vilari O Guell C" first="Carles" last="Vilari O-Güell">Carles Vilari O-Güell</name>
</noRegion>
<name sortKey="Behrouz, Bahareh" sort="Behrouz, Bahareh" uniqKey="Behrouz B" first="Bahareh" last="Behrouz">Bahareh Behrouz</name>
<name sortKey="Cobb, Stephanie A" sort="Cobb, Stephanie A" uniqKey="Cobb S" first="Stephanie A." last="Cobb">Stephanie A. Cobb</name>
<name sortKey="Dachsel, Justus C" sort="Dachsel, Justus C" uniqKey="Dachsel J" first="Justus C." last="Dachsel">Justus C. Dachsel</name>
<name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J." last="Farrer">Matthew J. Farrer</name>
<name sortKey="Jasinska Myga, Barbara" sort="Jasinska Myga, Barbara" uniqKey="Jasinska Myga B" first="Barbara" last="Jasinska-Myga">Barbara Jasinska-Myga</name>
<name sortKey="Kachergus, Jennifer M" sort="Kachergus, Jennifer M" uniqKey="Kachergus J" first="Jennifer M." last="Kachergus">Jennifer M. Kachergus</name>
<name sortKey="Keeling, Brett H" sort="Keeling, Brett H" uniqKey="Keeling B" first="Brett H." last="Keeling">Brett H. Keeling</name>
<name sortKey="Melrose, Heather L" sort="Melrose, Heather L" uniqKey="Melrose H" first="Heather L." last="Melrose">Heather L. Melrose</name>
<name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A." last="Ross">Owen A. Ross</name>
<name sortKey="Soto Ortolaza, Alexandra I" sort="Soto Ortolaza, Alexandra I" uniqKey="Soto Ortolaza A" first="Alexandra I." last="Soto-Ortolaza">Alexandra I. Soto-Ortolaza</name>
<name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J." last="Uitti">Ryan J. Uitti</name>
<name sortKey="Wider, Christian" sort="Wider, Christian" uniqKey="Wider C" first="Christian" last="Wider">Christian Wider</name>
<name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name>
</country>
<country name="Pologne"><noRegion><name sortKey="Jasinska Myga, Barbara" sort="Jasinska Myga, Barbara" uniqKey="Jasinska Myga B" first="Barbara" last="Jasinska-Myga">Barbara Jasinska-Myga</name>
</noRegion>
</country>
<country name="Norvège"><region name="Trøndelag"><name sortKey="Aasly, Jan O" sort="Aasly, Jan O" uniqKey="Aasly J" first="Jan O" last="Aasly">Jan O. Aasly</name>
</region>
</country>
<country name="Canada"><noRegion><name sortKey="Rajput, Alex" sort="Rajput, Alex" uniqKey="Rajput A" first="Alex" last="Rajput">Alex Rajput</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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La maladie de Parkinson au Canada (serveur d'exploration)

LINGO1 rs9652490 is associated with Essential Tremor and Parkinson Disease

LINGO1 rs9652490 is associated with Essential Tremor and Parkinson Disease

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	La maladie de Parkinson au Canada (serveur d'exploration)
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